Necroptosis and tumor progression

• Published in: Trends in cancer Vol. 8; no. 1; p. 21
• Main Authors: Yan, Jiong, Wan, Peixing, Choksi, Swati, Liu, Zheng-Gang
• Format: Journal Article
• Language: English
• Published: United States 01.01.2022
• Subjects: Apoptosis - genetics; Humans; Necroptosis - genetics; Necrosis; Protein Kinases - metabolism; Receptor-Interacting Protein Serine-Threonine Kinases - metabolism; ZBP1; MLKL; RIPK3; metastasis; tumorigenesis; antitumor immunity; necroptosis

Necroptosis, a form of programmed necrotic cell death, is a gatekeeper of host defense against certain pathogen invasions. The deregulation of necroptosis is also a key factor of many inflammatory diseases. Recent studies have revealed an important role of necroptosis in tumorigenesis and metastasis...