Necroptosis and tumor progression

Necroptosis, a form of programmed necrotic cell death, is a gatekeeper of host defense against certain pathogen invasions. The deregulation of necroptosis is also a key factor of many inflammatory diseases. Recent studies have revealed an important role of necroptosis in tumorigenesis and metastasis...

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Bibliographic Details
Published inTrends in cancer Vol. 8; no. 1; p. 21
Main Authors Yan, Jiong, Wan, Peixing, Choksi, Swati, Liu, Zheng-Gang
Format Journal Article
LanguageEnglish
Published United States 01.01.2022
Subjects
Apoptosis - genetics
Humans
Necroptosis - genetics
Necrosis
Protein Kinases - metabolism
Receptor-Interacting Protein Serine-Threonine Kinases - metabolism
ZBP1
MLKL
RIPK3
metastasis
tumorigenesis
antitumor immunity
necroptosis
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Summary:Necroptosis, a form of programmed necrotic cell death, is a gatekeeper of host defense against certain pathogen invasions. The deregulation of necroptosis is also a key factor of many inflammatory diseases. Recent studies have revealed an important role of necroptosis in tumorigenesis and metastasis and imply the potential of targeting necroptosis as a novel cancer therapy. While its molecular mechanism has been well studied, details of the regulation and function of necroptosis of tumor cells in tumorigenesis and metastasis only began to emerge recently, and we discuss these herein.
ISSN:2405-8025
DOI:10.1016/j.trecan.2021.09.003