Necroptosis and tumor progression
Necroptosis, a form of programmed necrotic cell death, is a gatekeeper of host defense against certain pathogen invasions. The deregulation of necroptosis is also a key factor of many inflammatory diseases. Recent studies have revealed an important role of necroptosis in tumorigenesis and metastasis...
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| Published in | Trends in cancer Vol. 8; no. 1; p. 21 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
01.01.2022
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| Subjects | |
| Online Access | Get more information |
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| Abstract | Necroptosis, a form of programmed necrotic cell death, is a gatekeeper of host defense against certain pathogen invasions. The deregulation of necroptosis is also a key factor of many inflammatory diseases. Recent studies have revealed an important role of necroptosis in tumorigenesis and metastasis and imply the potential of targeting necroptosis as a novel cancer therapy. While its molecular mechanism has been well studied, details of the regulation and function of necroptosis of tumor cells in tumorigenesis and metastasis only began to emerge recently, and we discuss these herein. |
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| AbstractList | Necroptosis, a form of programmed necrotic cell death, is a gatekeeper of host defense against certain pathogen invasions. The deregulation of necroptosis is also a key factor of many inflammatory diseases. Recent studies have revealed an important role of necroptosis in tumorigenesis and metastasis and imply the potential of targeting necroptosis as a novel cancer therapy. While its molecular mechanism has been well studied, details of the regulation and function of necroptosis of tumor cells in tumorigenesis and metastasis only began to emerge recently, and we discuss these herein. |
| Author | Liu, Zheng-Gang Yan, Jiong Choksi, Swati Wan, Peixing |
| Author_xml | – sequence: 1 givenname: Jiong surname: Yan fullname: Yan, Jiong organization: Laboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA – sequence: 2 givenname: Peixing surname: Wan fullname: Wan, Peixing organization: Laboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA – sequence: 3 givenname: Swati surname: Choksi fullname: Choksi, Swati organization: Laboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA – sequence: 4 givenname: Zheng-Gang surname: Liu fullname: Liu, Zheng-Gang email: zgliu@box-z.nih.gov organization: Laboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: zgliu@box-z.nih.gov |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/34627742$$D View this record in MEDLINE/PubMed |
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