Novel bright-emission small-molecule NIR-II fluorophores for in vivo tumor imaging and image-guided surgery

Though high brightness and biocompatible small NIR-II dyes are highly desirable in clinical or translational cancer research, their fluorescent cores are relatively limited and their synthetic processes are somewhat complicated. Herein, we have explored the design and synthesis of novel NIR-II fluor...

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Published inChemical science (Cambridge) Vol. 8; no. 5; pp. 3489 - 3493
Main Authors Sun, Yao, Ding, Mingmin, Zeng, Xiaodong, Xiao, Yuling, Wu, Huaping, Zhou, Hui, Ding, Bingbing, Qu, Chunrong, Hou, Wei, Er-bu, A. G. A., Zhang, Yejun, Cheng, Zhen, Hong, Xuechuan
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 01.05.2017
Subjects
Backbone
Biocompatibility
Chemistry
Chemistry, Multidisciplinary
Fluorescence
Imaging
Lymph
Mice
Physical Sciences
Science & Technology
Surgery
Tumors
AG2S QUANTUM DOTS
REAL-TIME VISUALIZATION
METASTASIS
FLUORESCENCE
LIGHT
DISEASE-FREE SURVIVAL
COMPLETE RESECTION
CANCER
MOUSE MODELS
BRAIN
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Summary:Though high brightness and biocompatible small NIR-II dyes are highly desirable in clinical or translational cancer research, their fluorescent cores are relatively limited and their synthetic processes are somewhat complicated. Herein, we have explored the design and synthesis of novel NIR-II fluorescent materials (H1) without tedious chromatographic isolation with improved fluorescence performance (QY approximate to 2%) by introducing 2-amino 9,9-dialkyl-substituted fluorene as a donor into the backbone. Several types of water-soluble and biocompatible NIR-II probes: SXH, SDH, and H1 NPs were constructed via different chemical strategies based on H1, and then their potential to be used in in vivo tumor imaging and image-guided surgery in the NIR-II region was explored. High levels of uptake were obtained for both passive and active tumor targeting probes SXH and SDH. Furthermore, high resolution imaging of blood vessels on tumors and the whole body of living mice using H1 NPs for the first time has demonstrated precise NIR-II image-guided sentinel lymph node (SLN) surgery.
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ISSN:2041-6520
2041-6539
DOI:10.1039/c7sc00251c