Anti-diabetic effect of three new norditerpenoid alkaloids in vitro and potential mechanism via PI3K/Akt signaling pathway

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Bibliographic Details
Published inBiomedicine & pharmacotherapy Vol. 87; pp. 145 - 152
Main Authors Tang, Dan, Chen, Qi-Bin, Xin, Xue-Lei, Aisa, Haji-Akber
Format Journal Article
LanguageEnglish
Published France Elsevier Masson SAS 01.03.2017
Subjects
Animals
Anti-diabetic activity
Cells, Cultured
Diabetes
Diterpenes - isolation & purification
Diterpenes - pharmacology
Glucose - agonists
Glucose - metabolism
Hypoglycemic Agents - isolation & purification
Hypoglycemic Agents - pharmacology
Internal Medicine
Medical Education
Nigella
Norditerpenoid alkaloids
Phosphatidylinositol 3-Kinases - metabolism
PI3K/Akt signaling pathway
Plant Extracts - isolation & purification
Plant Extracts - pharmacology
Protein tyrosine phosphatase 1B
Proto-Oncogene Proteins c-akt - metabolism
Rats
Seeds
Signal Transduction - drug effects
Signal Transduction - physiology
Protein tyrosine phosphatase 1B
Glucose metabolism
Norditerpenoid alkaloids
Diabetes
Anti-diabetic activity
PI3K/Akt signaling pathway
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Summary:Graphical abstract
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0753-3322
1950-6007
DOI:10.1016/j.biopha.2016.12.058