XPA: A key scaffold for human nucleotide excision repair

Nucleotide excision repair (NER) is essential for removing many types of DNA lesions from the genome, yet the mechanisms of NER in humans remain poorly understood. This review summarizes our current understanding of the structure, biochemistry, interaction partners, mechanisms, and disease-associate...

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Bibliographic Details
Published inDNA repair Vol. 44; pp. 123 - 135
Main Authors Sugitani, Norie, Sivley, Robert M., Perry, Kelly E., Capra, John A., Chazin, Walter J.
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.08.2016
Subjects
Amino Acid Sequence
Animals
DNA - chemistry
DNA - metabolism
DNA Damage
DNA Repair
Humans
Models, Molecular
Mutation
NER
Protein Binding
Protein Domains
Protein Interaction Mapping
Protein Structure, Secondary
Severity of Illness Index
Xeroderma pigmentosum
Xeroderma Pigmentosum - genetics
Xeroderma Pigmentosum - metabolism
Xeroderma Pigmentosum - pathology
Xeroderma Pigmentosum Group A Protein - chemistry
Xeroderma Pigmentosum Group A Protein - genetics
Xeroderma Pigmentosum Group A Protein - metabolism
XPA
RPA
DDB
PCNA
(6-4)PP
TTD
FL
AAF
XPA
Xeroderma pigmentosum
CAK
APIM
DNA repair
NLS
TFIIH
CPD
XP
NER
WT
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Summary:Nucleotide excision repair (NER) is essential for removing many types of DNA lesions from the genome, yet the mechanisms of NER in humans remain poorly understood. This review summarizes our current understanding of the structure, biochemistry, interaction partners, mechanisms, and disease-associated mutations of one of the critical NER proteins, XPA.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1568-7864
1568-7856
DOI:10.1016/j.dnarep.2016.05.018