Association of Pulse Pressure with Serum TNF-α and Neutrophil Count in the Elderly

• Published in: Journal of diabetes research Vol. 2014; no. 2014; pp. 1 - 7
• Main Authors: Kazumi, Tsutomu, Kurata, Miki, Takeuchi, Mika, Yamada, Eriko, Fukuo, Keisuke
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 01.01.2014; Hindawi Limited; Wiley
• Subjects: Age; Age Factors; Aged; Aged, 80 and over; Aging - blood; Aging - immunology; Antihypertensives; Automation; Biomarkers - blood; Blood Pressure; Body mass index; Cholesterol; Creatinine; Cross-Sectional Studies; Cytokines; Diabetes; Diabetes Mellitus, Type 2 - epidemiology; Diabetes Mellitus, Type 2 - physiopathology; Female; Glucose; Homeostasis; Humans; Hypertension - diagnosis; Hypertension - epidemiology; Hypertension - physiopathology; Inflammation; Inflammation - blood; Inflammation - diagnosis; Inflammation - epidemiology; Inflammation - immunology; Inflammation Mediators - blood; Insulin Resistance; Japan - epidemiology; Leukocyte Count; Neutrophils; Neutrophils - immunology; Older people; Predictive Value of Tests; Regression analysis; Risk Factors; Tumor Necrosis Factor-alpha - blood; Tumor necrosis factor-TNF; Variables; Variance analysis; Japan
• ISSN: 2314-6745; 2314-6753
• DOI: 10.1155/2014/972431

Aims. Elevated pulse pressure (PP) has been reported to be a risk factor for type 2 diabetes in elderly patients with hypertension. Methods. Cross-sectional relationships of PP with known risk factors for type 2 diabetes and inflammatory markers were examined in 150 elderly community-dwelling women, 79 women (52.7%) of whom had hypertension. Results. Systolic blood pressure (standardized β, 0.775), log tumor necrosis factor-α (TNF-α, standardized β, 0.110), age (standardized β, 0.140), and neutrophil count (standardized β, 0.114) emerged as determinants of PP independent of high-sensitivity C-reactive protein, interleukin-6, monocyte count, plasminogen activator inhibitor-1, homeostasis model assessment of insulin resistance, HDL-cholesterol, and adiponectin (R2 = 0.772). Conclusions. The present studies have demonstrated an independent association of higher PP with higher TNF-α, a marker of insulin resistance, and neutrophil count in community-living elderly women and suggest that insulin resistance and chronic low-grade inflammation may in part be responsible for the association between high PP and incident type 2 diabetes found in elderly patients with hypertension.