Fever and the control of gram-negative bacteria

• Published in: Research in microbiology Vol. 145; no. 4; pp. 269 - 272
• Main Authors: Green, M.H., Vermeulen, C.W.
• Format: Journal Article
• Language: English
• Published: Paris Elsevier SAS 1994; Elsevier
• Subjects: Bacteria, Temperature, Iron, Enterobacteria, Gram-negatives; Bacteriology; Biological and medical sciences; Body Temperature; Complement Pathway, Alternative - physiology; Enterobacter; Escherichia coli; Fever - etiology; Fever, LPS, Complement, Infection; Fundamental and applied biological sciences. Psychology; Gram-Negative Bacteria - metabolism; Gram-Negative Bacteria - pathogenicity; Gram-Negative Bacterial Infections - complications; Gram-Negative Bacterial Infections - immunology; Humans; Lipopolysaccharides - biosynthesis; Microbiology; Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains; Salmonella; Times and Trends; Bacteria, Temperature, Iron, Enterobacteria, Gram-negatives; Times and Trends; Fever, LPS, Complement, Infection; Infection; Sensitivity; Bacteriosis; Lipopolysaccharide; Host agent relation; Serum; Complement; Mechanism of action; Defense; Fever; Bactericidal effect; Gram negative bacteria
• ISSN: 0923-2508; 1769-7123
• DOI: 10.1016/0923-2508(94)90182-1

Although it seems obvious that fever has some important general adaptive value, it is still not clear by what means this function is manifested. One postulate is that febrile conditions result in the sequestration of soluble iron, effectively starving some pathogens of that essential nutrient. On the basis of our recent experiments, we propose a new mechanism for how fever serves to restrict a wide range of Gram-negative bacteria. The elevated temperature prevents the bacteria from synthesizing their protective LPS, thereby enabling serum complement to perforate and kill the invading pathogens even prior to the production of host antibodies.