TOPping Off Meiosis

• Published in: Molecular cell Vol. 57; no. 4; pp. 577 - 581
• Main Author: Haber, James E.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 19.02.2015
• Subjects: Chromosome Segregation; DNA Topoisomerases, Type I - physiology; DNA-Binding Proteins - physiology; Homologous Recombination - physiology; Humans; Meiosis - genetics; Models, Genetic; Rad51 Recombinase - physiology; RecQ Helicases - physiology; Saccharomyces cerevisiae - genetics; Saccharomyces cerevisiae Proteins - physiology

Double-strand breaks (DSBs) threaten chromosome integrity. The most accurate repair of DSBs is by homologous recombination (HR), catalyzed by recombination proteins such as Rad51. Three papers in this issue of Molecular Cell (Fasching et al., 2015; Kaur et al., 2015; Tang et al., 2015) now reveal th...