TOPping Off Meiosis

Double-strand breaks (DSBs) threaten chromosome integrity. The most accurate repair of DSBs is by homologous recombination (HR), catalyzed by recombination proteins such as Rad51. Three papers in this issue of Molecular Cell (Fasching et al., 2015; Kaur et al., 2015; Tang et al., 2015) now reveal th...

Full description

Saved in:
Bibliographic Details
Published inMolecular cell Vol. 57; no. 4; pp. 577 - 581
Main Author Haber, James E.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 19.02.2015
Subjects
Chromosome Segregation
DNA Topoisomerases, Type I - physiology
DNA-Binding Proteins - physiology
Homologous Recombination - physiology
Humans
Meiosis - genetics
Models, Genetic
Rad51 Recombinase - physiology
RecQ Helicases - physiology
Saccharomyces cerevisiae - genetics
Saccharomyces cerevisiae Proteins - physiology
Online AccessGet full text

Cover

More Information
Summary:Double-strand breaks (DSBs) threaten chromosome integrity. The most accurate repair of DSBs is by homologous recombination (HR), catalyzed by recombination proteins such as Rad51. Three papers in this issue of Molecular Cell (Fasching et al., 2015; Kaur et al., 2015; Tang et al., 2015) now reveal the role of three of these proteins in budding yeast: Sgs1 (BLM homolog), Top3 (TOPIIIα homolog), and Rmi1. They demonstrate several steps where all three proteins act together, and find additional functions of the Top3-Rmi1 subcomplex that are critical for the completion of meiosis.
Bibliography:SourceType-Scholarly Journals-1
ObjectType-Commentary-2
ObjectType-Feature-4
content type line 23
ObjectType-Review-1
ObjectType-Article-3
ISSN:1097-2765
1097-4164
DOI:10.1016/j.molcel.2015.02.004