Urinary Sediments as Predictors of the Histopathology of Lupus Nephritis

• Published in: Saudi journal of kidney diseases and transplantation Vol. 33; no. 5; pp. 617 - 626
• Main Authors: Gamaleldin, Sally, Alghazaly, Ghada, Saad, Mohammed, Shareef, Mohamed, Elnagar, Gamal
• Format: Journal Article
• Language: English
• Published: Riyadh Medknow Publications and Media Pvt. Ltd 01.09.2022; Medknow Publications & Media Pvt. Ltd; Wolters Kluwer Medknow Publications
• Subjects: Analysis; Biopsy; Histochemistry; Histopathology; Lupus; Nephritis; Risk factors; Systemic lupus erythematosus; Urine
• ISSN: 1319-2442; 2320-3838
• DOI: 10.4103/1319-2442.389422

Lupus nephritis (LN) is a major risk factor for morbidity and mortality in systemic lupus erythematosus (SLE). Urinalysis has an invaluable role in the diagnosis of various renal and urological diseases. Examinations of the urinary sediment using phase contrast microscopy (PCM) may add more information to help earlier diagnoses of LN. This cross-sectional study aimed to assess the possible role of the components of urinary sediment examined using PCM in discriminating the proliferative classes of LN (III and IV ± V) from the non-proliferative classes (I, II, and V), and to detect the correlation between the components of urinary sediment and indices of both activity and chronicity found by the renal biopsy. The study was conducted on 40 SLE patients for whom a renal biopsy was indicated. Clinical, demographic, and laboratory data and the results of the histopathological renal biopsy were collected. The morning before the renal biopsy; urine samples were collected from every patient and examined by PCM. Receiver operating characteristic curves were used to detect the area under the curve to predict proliferative LN. The correlations of counts of leukocytes, erythrocytes, all dysmorphic erythrocytes, acanthocytes, and stomatocytes with the indices of activity and chronicity were significant (activity: P = 0.027, P = 0.015, P = 0.033, P = 0.040, and P <0.001*; chronicity: P = 0.035, P = 0.009, P = 0.027, P = 0.010, and P <0.001, respectively). For patients with SLE, urinary sediment examinations can suggest a renal biopsy for the histopathology of LN.