Effects of glycine–metal compounds on Ascaridia galli-infected chickens expressed by a kinetic model

• Published in: Journal of helminthology Vol. 78; no. 1; pp. 25 - 32
• Main Authors: Gabrashanska, M, Teodorova, S.E, Galvez-Morros, M, Mitov, M
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 01.03.2004
• Subjects: Animals; Ascaridia - physiology; Ascaridia galli; Ascaridiasis - immunology; Ascaridiasis - metabolism; Ascaridiasis - therapy; Biological and medical sciences; Biological Availability; Body Weight; Chickens; cobalt; Cobalt - administration & dosage; dietary mineral supplements; Dietary Supplements; Fundamental and applied biological sciences. Psychology; Host parasite relation; pathogenicity; Host-Parasite Interactions; Invertebrates; Liver - metabolism; liveweight gain; Male; manganese; Manganese - administration & dosage; mathematical models; mineral content; Minerals - administration & dosage; Models, Biological; mortality; Nemathelminthia. Plathelmintha; nutrient deficiencies; population dynamics; Poultry Diseases - immunology; Poultry Diseases - metabolism; Poultry Diseases - therapy; trace elements; zinc; Zinc - administration & dosage; Parasite; Metal; Glycine; Kinetic model; Vertebrata; Ascaridia galli; Helmintha; Neurotransmitter; Nemathelminthia; Chicken; Aves; Invertebrata; Nematoda
• ISSN: 0022-149X; 1475-2697
• DOI: 10.1079/JOH2003204

The biogenic elements zinc, manganese and cobalt are essential for metabolic processes in animals. Compounds of nGly.Me2+A. mH2O (Me2+=Zn2+, Mn2+, Co2+; A=Cl−, SO42−, n=1, 2; m=2, 5), as supplements in the diet, were used separately on different experimental groups of male Hisex chickens to correct the mineral deficiency caused by Ascaridia galli infections. An amelioration of body weight gain, reduction of mortality and restoration of trace element levels were estimated in infected chickens. A mathematical model has been proposed for A. galli population kinetics in chickens, taking into account the stimulating effect of these elements on the nematodes. The model parameters are considered as phenomenological constants of the host–parasite system. An agreement with experimental data is observed using, for the parameters ψ, α, μ and μs, values equal to those calculated in previously investigated A. galli–chicken systems. For parameter ν (immunological constant) the same value was obtained as in a previous experiment with high infection. This model is likely to be suitable for a range of host–nematode systems, including varying degrees of infection and treatment with different trace elements.