Dr. Tetsuro Fujiwara-My Memories from the Early Days of Dr. Fujiwara's Research

This brief commentary honors Dr. Tesuro Fujiwara, the first person to treat infants with respiratory distress syndrome by instilling surfactant into their trachea. In the 1960s, mortality from RDS, which could only be treated with oxygen, was about 50 percent. Based on the physiology Fujiwara learne...

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Bibliographic Details
Published inBiomedicines Vol. 12; no. 1; p. 218
Main Author Jobe, Alan H
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 01.01.2024
Subjects
Animal models
Bovine spongiform encephalopathy
Conflicts of interest
Continuous positive airway pressure
Fujiwara
Infant mortality
Infants
Lungs
Mechanical ventilation
mortality
Newborn babies
Patient outcomes
Premature babies
prematurity
Respiratory distress syndrome
Sheep
Surface active agents
surfactant
Surfactants
Japan
Europe
mortality
prematurity
Fujiwara
surfactant
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Summary:This brief commentary honors Dr. Tesuro Fujiwara, the first person to treat infants with respiratory distress syndrome by instilling surfactant into their trachea. In the 1960s, mortality from RDS, which could only be treated with oxygen, was about 50 percent. Based on the physiology Fujiwara learned that lung immaturity could be treated with doses of surfactant from animals in sheep models. He then made a surfactant from cow lungs called Servanta and treated 10 infants with RDS, who all had a large improvement in oxygenation. Other new therapies, such as continuous positive airway pressure and newer infant ventilators-in combination with surfactant therapy have decreased infant mortality to less than 1% from RDS in the most recent US infant death statistics.
Bibliography:ObjectType-Article-1
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ISSN:2227-9059
2227-9059
DOI:10.3390/biomedicines12010218