Th17 and Regulatory T Cells in Mediating and Restraining Inflammation

• Published in: Cell Vol. 140; no. 6; pp. 845 - 858
• Main Authors: Littman, Dan R., Rudensky, Alexander Y.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 19.03.2010
• Subjects: Bacteria - immunology; Immune Tolerance; Inflammation - immunology; Inflammation - pathology; Intestinal Mucosa - microbiology; T-Lymphocytes, Helper-Inducer - immunology; T-Lymphocytes, Regulatory - immunology

The vertebrate immune system is poised in a state of equilibrium that permits accurate and rapid protective responses against pathogens but curtails potential for causing harm to the host through targeting of “self” and provoking overexuberant inflammatory processes. In this Review we discuss this b...