Th17 and Regulatory T Cells in Mediating and Restraining Inflammation

The vertebrate immune system is poised in a state of equilibrium that permits accurate and rapid protective responses against pathogens but curtails potential for causing harm to the host through targeting of “self” and provoking overexuberant inflammatory processes. In this Review we discuss this b...

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Bibliographic Details
Published inCell Vol. 140; no. 6; pp. 845 - 858
Main Authors Littman, Dan R., Rudensky, Alexander Y.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 19.03.2010
Subjects
Bacteria - immunology
Immune Tolerance
Inflammation - immunology
Inflammation - pathology
Intestinal Mucosa - microbiology
T-Lymphocytes, Helper-Inducer - immunology
T-Lymphocytes, Regulatory - immunology
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Summary:The vertebrate immune system is poised in a state of equilibrium that permits accurate and rapid protective responses against pathogens but curtails potential for causing harm to the host through targeting of “self” and provoking overexuberant inflammatory processes. In this Review we discuss this balance achieved in large part by interactions of different classes of T lymphocytes that have potent pro- or anti-inflammatory activity in the context of genetic and environmental factors, particularly the commensal microbiota.
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ISSN:0092-8674
1097-4172
0020-7683
1097-4172
DOI:10.1016/j.cell.2010.02.021