Angiotensin II Type I Receptor Agonistic Autoantibody Induces Podocyte Injury via Activation of the TRPC6- Calcium/Calcineurin Pathway in Pre-Eclampsia

• Published in: Kidney & blood pressure research Vol. 43; no. 5; pp. 1666 - 1676
• Main Authors: Yu, Ying, Zhang, Lihong, Xu, Guang, Wu, Zhenghong, Li, Qian, Gu, Yong, Niu, Jianying
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland S. Karger AG 01.01.2018; Karger Publishers
• Subjects: Actin; Activation; Adult; Angiotensin; Angiotensin II; Angiotensin II type I receptor agonistic autoantibody /AT1-AA; Apoptosis; Autoantibodies; Autoantibodies - blood; Autoantibodies - pharmacology; Calcineurin; Calcineurin - metabolism; Calcium; Calcium (intracellular); Calcium - metabolism; Calcium ions; Calcium/calcineurin; Cells, Cultured; Change detection; Chromatography; Endothelin 1; Endothelins; Enzyme-linked immunosorbent assay; Female; Hospitals; Humans; Hypertension; Immunofluorescence; Inhibitors; Intracellular; Kidney diseases; Kinases; Metabolic Networks and Pathways - drug effects; Original Paper; Peptides; Phosphorylation; Podocyte; Podocytes - drug effects; Podocytes - metabolism; Podocytes - pathology; Pre-eclampsia; Pre-Eclampsia - blood; Pre-Eclampsia - metabolism; Preeclampsia; Pregnancy; Proteins; Proteinuria; Receptor, Angiotensin, Type 1 - immunology; Receptor, Angiotensin, Type 1 - therapeutic use; siRNA; TRPC6; TRPC6 Cation Channel - metabolism; Vasoconstriction; United States > US; China; Podocyte; Angiotensin II type I receptor agonistic autoantibody /AT1-AA; TRPC6; Pre-eclampsia; Calcium/calcineurin

Background/Aims: Angiotensin II type I receptor agonistic autoantibody (AT1-AA) is closely related to pre-eclampsia, which is characterized by proteinuria and hypertension. AT1-AA has been shown to enhance the effect of AngII in pre-eclampsia, such as production of endothelin-1, activation of ROS, a...