A multicenter comparison of the safety of oral versus intravenous acetylcysteine for treatment of acetaminophen overdose

• Published in: Clinical toxicology (Philadelphia, Pa.) Vol. 48; no. 5; pp. 424 - 430
• Main Authors: Bebarta, Vikhyat S, Kao, Louise, Froberg, Blake, Clark, Richard F, Lavonas, Eric, Qi, Ming, Delgado, Joao, McDonagh, John, Arnold, Tom, Odujebe, Oladapo, O'Malley, Gerry, Lares, Claudia, Aguilera, Elizabeth, Dart, Richard, Heard, Kennon, Stanford, Chriss, Kokko, Jamie, Bogdan, Greg, Mendoza, Carrie, Mlynarchek, Sara, Rhyee, Sean, Hoppe, Jason, Haur, William, Tan, Hock Heng, Tran, Nguyen Nguyen, Varney, Shawn, Zosel, Amy, Buchanan, Jennifer, Al-Helial, Mohammed
• Format: Journal Article
• Language: English
• Published: England Informa UK Ltd 01.06.2010; Taylor & Francis
• Subjects: Acetaminophen; Acetaminophen - poisoning; Acetylcysteine - administration & dosage; Acetylcysteine - poisoning; Acetylcysteine - therapeutic use; Acute poisoning; Anaphylaxis - chemically induced; Drug Administration Routes; Drug Overdose - drug therapy; Humans; Infusions, Intravenous; Injections, Intravenous; N-Acetylcysteine; Nausea - chemically induced; Nausea - drug therapy; Safety; Treatment Outcome; Vomiting - chemically induced; Vomiting - drug therapy

Oral and intravenous (IV) N-acetylcysteine (NAC) are used for the treatment of acetaminophen poisoning. The objective of this multicenter study was to compare the safety of these two routes of administration. Methods. We conducted a multicenter chart review of all patients treated with NAC for aceta...