A multicenter comparison of the safety of oral versus intravenous acetylcysteine for treatment of acetaminophen overdose
Oral and intravenous (IV) N-acetylcysteine (NAC) are used for the treatment of acetaminophen poisoning. The objective of this multicenter study was to compare the safety of these two routes of administration. Methods. We conducted a multicenter chart review of all patients treated with NAC for aceta...
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| Published in | Clinical toxicology (Philadelphia, Pa.) Vol. 48; no. 5; pp. 424 - 430 |
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| Main Authors | , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Informa UK Ltd
01.06.2010
Taylor & Francis |
| Subjects | |
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| Abstract | Oral and intravenous (IV) N-acetylcysteine (NAC) are used for the treatment of acetaminophen poisoning. The objective of this multicenter study was to compare the safety of these two routes of administration. Methods. We conducted a multicenter chart review of all patients treated with NAC for acetaminophen poisoning. The primary safety outcome was the percentage of patients with NAC-related adverse events. Results. A total of 503 subjects were included in the safety analysis (306 IV-only, 145 oral-only, and 52 both routes). There were no serious adverse events related to NAC for either route. Nausea and vomiting were the most common related adverse events and were more common with oral treatment (23 vs. 9%). Anaphylactoid reactions were more common with IV administration (6 vs. 2%). Conclusions. IV and oral NAC are generally mild adverse drug reactions. |
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| AbstractList | Oral and intravenous (IV) N-acetylcysteine (NAC) are used for the treatment of acetaminophen poisoning. The objective of this multicenter study was to compare the safety of these two routes of administration. Methods. We conducted a multicenter chart review of all patients treated with NAC for acetaminophen poisoning. The primary safety outcome was the percentage of patients with NAC-related adverse events. Results. A total of 503 subjects were included in the safety analysis (306 IV-only, 145 oral-only, and 52 both routes). There were no serious adverse events related to NAC for either route. Nausea and vomiting were the most common related adverse events and were more common with oral treatment (23 vs. 9%). Anaphylactoid reactions were more common with IV administration (6 vs. 2%). Conclusions. IV and oral NAC are generally mild adverse drug reactions. Oral and intravenous (IV) N-acetylcysteine (NAC) are used for the treatment of acetaminophen poisoning. The objective of this multicenter study was to compare the safety of these two routes of administration. We conducted a multicenter chart review of all patients treated with NAC for acetaminophen poisoning. The primary safety outcome was the percentage of patients with NAC-related adverse events. A total of 503 subjects were included in the safety analysis (306 IV-only, 145 oral-only, and 52 both routes). There were no serious adverse events related to NAC for either route. Nausea and vomiting were the most common related adverse events and were more common with oral treatment (23 vs. 9%). Anaphylactoid reactions were more common with IV administration (6 vs. 2%). IV and oral NAC are generally mild adverse drug reactions. |
| Author | Varney, Shawn O'Malley, Gerry McDonagh, John Kao, Louise Buchanan, Jennifer Clark, Richard F Delgado, Joao Qi, Ming Rhyee, Sean Dart, Richard Tan, Hock Heng Mendoza, Carrie Stanford, Chriss Odujebe, Oladapo Mlynarchek, Sara Froberg, Blake Aguilera, Elizabeth Heard, Kennon Kokko, Jamie Haur, William Arnold, Tom Al-Helial, Mohammed Bogdan, Greg Bebarta, Vikhyat S Lares, Claudia Zosel, Amy Lavonas, Eric Tran, Nguyen Nguyen Hoppe, Jason |
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| SubjectTerms | Acetaminophen Acetaminophen - poisoning Acetylcysteine - administration & dosage Acetylcysteine - poisoning Acetylcysteine - therapeutic use Acute poisoning Anaphylaxis - chemically induced Drug Administration Routes Drug Overdose - drug therapy Humans Infusions, Intravenous Injections, Intravenous N-Acetylcysteine Nausea - chemically induced Nausea - drug therapy Safety Treatment Outcome Vomiting - chemically induced Vomiting - drug therapy |
| Title | A multicenter comparison of the safety of oral versus intravenous acetylcysteine for treatment of acetaminophen overdose |
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