Sex Determination in Sciarid Flies: a Model for the Control of Differential X-chromosome Elimination

In sciarids, all zygotes start development with the 3X;2A chromosome constitution, two of the three X chromosomes being of paternal origin. The elimination of either one or two paternal X chromosomes produces the X:A signal which determines development along the female (2X;2A) or male (X0;2A) pathwa...

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Bibliographic Details
Published inJournal of theoretical biology Vol. 197; no. 2; pp. 247 - 259
Main Authors Sánchez, Lucas, Perondini, André L.P.
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 21.03.1999
Subjects
chromosomal factor
chromosome elimination
embryo (animal)
genetic models
genetic regulation
maternal factor
Sciaridae
sex determination
sex ratio
somatic cells
X chromosome
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Summary:In sciarids, all zygotes start development with the 3X;2A chromosome constitution, two of the three X chromosomes being of paternal origin. The elimination of either one or two paternal X chromosomes produces the X:A signal which determines development along the female (2X;2A) or male (X0;2A) pathway, respectively. A model is proposed in which a chromosomal factor (CF) positively interacts with the X chromosome(s) causing its/their elimination. The number of X chromosomes to be eliminated is controlled by a maternal factor (MF) which regulates the amount of free CF factor interacting with the X chromosomes. Imprinting refers to the inability of maternal X chromosomes to bind CF factor.
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ISSN:0022-5193
1095-8541
DOI:10.1006/jtbi.1998.0868