8-OH-DPAT inhibits both prandial and waterspray-induced grooming

The effects of 8-OH-DPAT treatment on rat grooming behaviour, elicited either prandially or in response to spraying with water were investigated. Dose (< or =0.1 mg/kg s.c.) response studies employed momentary time sampling over 30 or 60 min with behaviour being scored in one of 6 or 7 (depending...

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Bibliographic Details
Published inJournal of psychopharmacology (Oxford) Vol. 22; no. 7; p. 746
Main Authors Hartley, J E, Montgomery, A M J
Format Journal Article
LanguageEnglish
Published United States 01.09.2008
Subjects
8-Hydroxy-2-(di-n-propylamino)tetralin - pharmacology
Animals
Dose-Response Relationship, Drug
Eating - drug effects
Eating - psychology
Grooming - drug effects
Male
Motor Activity - drug effects
Physical Stimulation
Rats
Rats, Sprague-Dawley
Satiety Response - drug effects
Serotonin Receptor Agonists - pharmacology
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Summary:The effects of 8-OH-DPAT treatment on rat grooming behaviour, elicited either prandially or in response to spraying with water were investigated. Dose (< or =0.1 mg/kg s.c.) response studies employed momentary time sampling over 30 or 60 min with behaviour being scored in one of 6 or 7 (depending on food availability) mutually exclusive categories (feeding, active, scratching, face-grooming, body grooming, genital-grooming and resting) at 15 s intervals. In non-deprived rats, tested with wet mash available, feeding and activity frequencies were increased, but resting and total grooming were inhibited by 8-OH-DPAT. Face-, body- and genital-grooming occurred at higher levels than scratching, but all categories were reduced with reductions in scratching occurring at a lower dose (0.01 mg/kg). Misting rats with a fine water spray selectively increased body grooming and decreased activity without altering feeding, while 8-OH-DPAT increased feeding and reduced face-, body- and genital-grooming, without affecting already low levels of scratching. In misted rats, tested without food, 8-OH-DPAT reduced face-, body- and genital-grooming and increased resting. These results confirm i) that the water spray technique is a useful method for increasing grooming and ii) that 8-OH-DPAT has a suppressant effect on grooming independent of response competition from enhanced feeding.
ISSN:0269-8811
DOI:10.1177/0269881107082903