Tenofovir induced Fanconi syndrome: A rare cause of hypokalemic paralysis

We report a 55-year-old female who presented to the emergency department with acute onset quadriparesis. She was diagnosed to have acquired immunodeficiency syndrome 7 years ago and was on tenofovir based anti-retroviral therapy for past 10 months. As the patient also had hypophosphatemia, glucosuri...

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Bibliographic Details
Published inIndian journal of nephrology Vol. 24; no. 2; pp. 108 - 109
Main Authors Venkatesan, E, Pranesh, M, Gnanashanmugam, G, Balasubramaniam, J
Format Journal Article
LanguageEnglish
Published India Medknow Publications 01.03.2014
Medknow Publications and Media Pvt. Ltd
Medknow Publications & Media Pvt. Ltd
Medknow Publications & Media Pvt Ltd
Subjects
Care and treatment
Case Report
Case studies
Complications and side effects
Diagnosis
Fanconi's anemia
Paralysis
Patient outcomes
Risk factors
Tenofovir
India
Fanconi syndrome
tenofovir
Anti-retroviral therapy
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Summary:We report a 55-year-old female who presented to the emergency department with acute onset quadriparesis. She was diagnosed to have acquired immunodeficiency syndrome 7 years ago and was on tenofovir based anti-retroviral therapy for past 10 months. As the patient also had hypophosphatemia, glucosuria and proteinuria Fanconi syndrome (FS) was suspected. She improved dramatically over next 12 h to regain normal power and also her renal functions improved over next few days. Tenofovir induced FS presenting as hypokalemic paralysis is very rare complication and is the first case reported from India.
ISSN:0971-4065
1998-3662
DOI:10.4103/0971-4065.127898