Anti-pruritic efficacies of doxycycline and erythromycin in the treatment of acne vulgaris: A randomized single-blinded pilot study

A study on human keratinocytes demonstrated that tetracycline attenuates the protease-activated receptor 2 interleukin-8 axis in the modulation of proinflammatory responses. Doxycycline was found to significantly reduce pruritus in acne vulgaris and we postulate that in addition to a reduction in in...

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Published inIndian journal of dermatology, venereology, and leprology Vol. 84; no. 4; pp. 458 - 460
Main Authors Cao, Taige, Tan, Eugene, Chan, Yiong, Yosipovitch, Gil, Tey, Hong
Format Journal Article
LanguageEnglish
Published India Wolters Kluwer India Pvt. Ltd 01.07.2018
Scientific Scholar
Subjects
Acne
Antibiotics
Cytokines
Dermatology
Pruritus
Singapore
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Summary:A study on human keratinocytes demonstrated that tetracycline attenuates the protease-activated receptor 2 interleukin-8 axis in the modulation of proinflammatory responses. Doxycycline was found to significantly reduce pruritus in acne vulgaris and we postulate that in addition to a reduction in inflammation, attenuation of the protease-activated receptor 2 interleukin-8 pathway may contribute to this effect. [...]our results revealed that doxycycline effectively reduces itch intensity in pruritic acne and this effect was independent of improvements in acne severity.
Bibliography:SourceType-Other Sources-1
ObjectType-Correspondence-1
ObjectType-News-2
content type line 66
ObjectType-Article-3
ISSN:0378-6323
0973-3922
1998-3611
DOI:10.4103/ijdvl.IJDVL_41_17