Comparison of the Efficacy of Different Combined Therapies Based on Modified Core Decompression for the Treatment of Early‐stage Nontraumatic Osteonecrosis of the Femoral Head: A Retrospective Clinical Study

• Published in: Orthopaedic surgery Vol. 16; no. 8; pp. 1912 - 1919
• Main Authors: Sun, Shuo, Li, Donghai, Wang, Qin, Kang, Pengde
• Format: Journal Article
• Language: English
• Published: Melbourne John Wiley & Sons Australia, Ltd 01.08.2024; John Wiley & Sons, Inc; Wiley
• Subjects: Arthritis; Bones; Care and treatment; Clinical; Clinical trials; Comparative analysis; Direct anterior approach; General anesthesia; Homeopathy; Lightbulb; Magnetic resonance imaging; Materia medica and therapeutics; Necrosis; Nonvascularized allogeneic fibular; Osteoarthritis; Osteonecrosis of the femoral head; Radiography; Skin & tissue grafts; Surgery; Surgical outcomes; Surgical techniques; Therapeutics; Lightbulb; Direct anterior approach; Osteonecrosis of the femoral head; Nonvascularized allogeneic fibular
• ISSN: 1757-7853; 1757-7861
• DOI: 10.1111/os.14128

Objective Osteonecrosis of the femoral head (ONFH) is a severe orthopedic disease, which may cause severe hip dysfunction in later stage. Therefore, it is necessary to treat nontraumatic ONFH during the early stages. The aim of this study was to evaluate the clinical efficacy and survival rates of different combined therapies based on modified core decompression (CD) for early‐stage nontraumatic ONFH. Methods This retrospective cohort study assessed 397 hips with ONFH who underwent different combined therapies based on modified CD in our institution between January 2010 and December 2017. Patients were classified into six groups based on treatment modalities, and were followed up at 1 year and 5 years postoperatively. Clinical outcomes, including Harris hip score (HHS) and Western Ontario and McMaster Universities osteoarthritis index (WOMAC), were compared to evaluate the hip function and quick rehabilitation effect. Radiographic progression of ONFH and the incidence of total hip arthroplasty were analyzed to evaluate the survival rate of ONFH postoperatively. Statistical analyses were mainly performed with Kruskal–Wallis test, chi‐square test and Kaplan–Meier method. Results HHS increased significantly in all groups but showed no significant differences among the six groups in the first years. The nonvascularized allogeneic fibula with bone grafting (NVAF + BG) and percutaneous femoral neck–head fenestration with bone grafting via the direct anterior approach (DAA + BG) groups had significantly higher HHS (p = 0.010; p = 0.025) and WOMAC function score (p < 0.001; p = 0.012) than the CD group 5 years postoperatively. Compared with the CD group, all the other groups showed statistically significant differences in radiographic progression (p < 0.001) and a higher survival rate with no significant difference (p = 0.569). Conclusion Our study demonstrates the potential use of NVAF + BG and DAA + BG, may serve as a promising combined therapy for the treatment of early‐stage nontraumatic ONFH. Flow diagram of patient selection and exclusion.