Mutually reinforced multicomponent polysaccharide networks
Networks made from chitosan and alginate have been utilized as prospective tissue engineering scaffolds due to material biocompatibility and degradability. Calcium (Ca2+) is often added to these networks as a modifier for mechanical strength enhancement. In this work, we examined changes in the bulk...
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Published in | Biopolymers Vol. 95; no. 12; pp. 840 - 851 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Hoboken
Wiley Subscription Services, Inc., A Wiley Company
01.12.2011
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Subjects | |
Online Access | Get full text |
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Summary: | Networks made from chitosan and alginate have been utilized as prospective tissue engineering scaffolds due to material biocompatibility and degradability. Calcium (Ca2+) is often added to these networks as a modifier for mechanical strength enhancement. In this work, we examined changes in the bulk material properties of different concentrations of chitosan/alginate mixtures (2, 3, or 5% w/w) upon adding another modifier, chondroitin. We further examined how material properties depend on the order the modifiers, Ca2+ and chondroitin, were added. It was found that the addition of chondroitin significantly increased the mechanical strength of chitosan/alginate networks. Highest elastic moduli were obtained from samples made with mass fractions of 5% chitosan and alginate, modified by chondroitin first and then Ca2+. The elastic moduli in dry and hydrated states were (4.41 ± 0.52) MPa and (0.11 ± 0.01) MPa, respectively. Network porosity and density were slightly dependent on total polysaccharide concentration. Average pore size was slightly larger in samples modified by Ca2+ first and then chondroitin and in samples made with 3% starting mass fractions. Here, small‐angle neutron scattering (SANS) was utilized to examine mesh size of the fibrous networks, mass‐fractal parameters and average dimensions of the fiber cross‐sections prior to freeze‐drying. These studies revealed that addition of Ca2+ and chondroitin modifiers increased fiber compactness and thickness, respectively. Together these findings are consistent with improved network mechanical properties of the freeze‐dried materials. © 2011 Wiley Periodicals, Inc. Biopolymers 95: 840–851, 2011. |
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Bibliography: | ark:/67375/WNG-JB7717TD-M istex:34D4B762E85D672379556CA7363019D72F975ECA ArticleID:BIP21687 Maryland Technology Development Corporation (TEDCO) NIH - No. EB004416 This article was originally published online as an accepted preprint. The "Published Online" date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at biopolymers@wiley.com National Science Foundation - No. DMR-0944772 This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at biopolymers@wiley.com ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0006-3525 1097-0282 1097-0282 |
DOI: | 10.1002/bip.21687 |