Guidelines for establishing locus specific databases
Information about genetic variation has been collected for some 20 years into registries, known as locus specific databases (LSDBs), which nowadays often contain information in addition to the actual genetic variation. Several issues have to be taken into account when considering establishing and ma...
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Published in | Human mutation Vol. 33; no. 2; pp. 298 - 305 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Hoboken
Wiley Subscription Services, Inc., A Wiley Company
01.02.2012
Hindawi Limited |
Subjects | |
Online Access | Get full text |
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Summary: | Information about genetic variation has been collected for some 20 years into registries, known as locus specific databases (LSDBs), which nowadays often contain information in addition to the actual genetic variation. Several issues have to be taken into account when considering establishing and maintaining LSDBs and these have been discussed previously in a number of articles describing guidelines and recommendations. This information is widely scattered and, for a newcomer, it would be difficult to obtain the latest information and guidance. Here, a sequence of steps essential for establishing an LSDB is discussed together with guidelines for each step. Curators need to collect information from various sources, code it in systematic way, and distribute to the research and clinical communities. In doing this, ethical issues have to be taken into account. To facilitate integration of information to, for example, analyze genotype–phenotype correlations, systematic data representation using established nomenclatures, data models, and ontologies is essential. LSDB curation and maintenance comprises a number of tasks that can be managed by following logical steps. These resources are becoming ever more important and new curators are essential to ensure that we will have expertly curated databases for all disease‐related genes in the near future. Hum Mutat 33:298–305, 2012. © 2011 Wiley Periodicals, Inc. |
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Bibliography: | Communicated by Mark H. Paalman istex:920E1EF981F8F79BB5BAEA435F0D73B83AB524B6 European Community's Seventh Framework Programme (FP7/2007-2013; 200754) ark:/67375/WNG-2DRBZSJD-Q ArticleID:HUMU21646 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1059-7794 1098-1004 |
DOI: | 10.1002/humu.21646 |