Quantification of intramyocellular lipids in obese subjects using spectroscopic imaging with high spatial resolution

• Published in: Magnetic resonance in medicine Vol. 57; no. 1; pp. 22 - 28
• Main Authors: Weis, J., Johansson, L., Courivaud, F., Karlsson, F.A., Ahlström, H.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.01.2007
• Subjects: Adult; Body Mass Index; Female; Humans; Image Enhancement; intramyocellular lipids; Leg; Lipids - analysis; Magnetic Resonance Spectroscopy - methods; MEDICIN; MEDICINE; Middle Aged; Muscle Fibers, Skeletal - chemistry; Muscle Fibers, Skeletal - metabolism; Muscle Fibers/chemistry/metabolism; Muscle, Skeletal - chemistry; Muscle, Skeletal - metabolism; Obesity; quantitation; Reference Values; skeletal muscle; spectroscopic imaging; Muscle; Skeletal/chemistry/metabolism
• ISSN: 0740-3194; 1522-2594; 1522-2594
• DOI: 10.1002/mrm.21085

Quantification of intramyocellular lipids (IMCL) in obese subjects by single‐voxel spectroscopy (SVS) or conventional spectroscopic imaging (SI) often fails due to overlap of IMCL spectral lines by extramyocellular lipids (EMCL), and signal contamination from subcutaneous fat and bone marrow. This study demonstrates that these problems can be solved by high‐resolution SI with 128 phase‐encoding steps and a read gradient during acquisition. The small voxels obtained in this way facilitated differentiation between EMCL and IMCL. This method offers the possibility of studying different muscle groups and the variation of lipids within one muscle. Magn Reson Med 57:22–28, 2007. © 2006 Wiley‐Liss, Inc.