Genetic factor in malignant melanoma

A study of 113 family histories from a total of 125 consecutive cases of malignant melanoma from Brisbane and surrounding areas, covering 923 first degree relatives, has shown a heritability of liability to this condition of approximately 11%. Evidence was found to suggest that the hereditary factor...

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Bibliographic Details
Published inCancer Vol. 27; no. 5; pp. 1262 - 1266
Main Authors Wallace, D. C., Exton, Lesley A., McLeod, G. R. C.
Format Journal Article
LanguageEnglish
Published New York Wiley Subscription Services, Inc., A Wiley Company 01.05.1971
Subjects
Adolescent
Adult
Age Factors
Aged
Australia
Child
Female
Humans
Male
Melanoma - epidemiology
Melanoma - genetics
Middle Aged
Pedigree
Sex Factors
Skin Neoplasms - epidemiology
Skin Neoplasms - genetics
Australia
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Summary:A study of 113 family histories from a total of 125 consecutive cases of malignant melanoma from Brisbane and surrounding areas, covering 923 first degree relatives, has shown a heritability of liability to this condition of approximately 11%. Evidence was found to suggest that the hereditary factor is polygenic in nature.
Bibliography:The Queensland Institute of Medical Research Brisbane, Australia.
Senior Research Fellow, The Queensland Melanoma Project, Brisbane, Australia.
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0008-543X
1097-0142
DOI:10.1002/1097-0142(197105)27:5<1262::AID-CNCR2820270534>3.0.CO;2-6