Toxoplasma gondii: a protozoan for the nineties

Toxoplasma gondii is growing in popularity as a model for studying intracellular parasitism. The parasite has also gained more attention recently as the most common cause of focal central nervous system infections in patients with AIDS and continues to cause more than 3,000 congenital infections per...

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Bibliographic Details
Published inInfection and immunity Vol. 61; no. 4; pp. 1169 - 1172
Main Authors JOINER, K. A, DUBREMETZ, J. F
Format Journal Article
LanguageEnglish
Published Washington, DC American Society for Microbiology 01.04.1993
Subjects
Animals
Biological and medical sciences
biological development
Cell Differentiation
Cytoskeletal Proteins - physiology
desarrollo biologico
developpement biologique
Fundamental and applied biological sciences. Psychology
Invertebrates
Life cycle. Host-agent relationship. Pathogenesis
Protozoa
Toxoplasma - physiology
Toxoplasma - ultrastructure
Toxoplasma gondii
Toxoplasmosis - parasitology
Toxoplasmosis - physiopathology
Infection
Protozoa
Life cycle
Host parasite relation
Motility
Toxoplasma gondii
Review
Sporozoa
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Summary:Toxoplasma gondii is growing in popularity as a model for studying intracellular parasitism. The parasite has also gained more attention recently as the most common cause of focal central nervous system infections in patients with AIDS and continues to cause more than 3,000 congenital infections per year in the United States alone. T. gondii infects nearly all animals and most birds and is one of the most widely distributed of all intracellular parasites. In vitro, tachyzoites of T. gondii can invade and replicate within essentially all nucleated cells, an unusual feat for any intracellular organism. Several advances necessary for more rapid progress are self-evident. These will be alluded to again below but are mentioned here for emphasis. Development of a transformation system for tachyzoites, identifying a means to grow tachyzoites axenically, and determining methods for growing bradyzoites in vitro in high yield stand out in importance in comparison with most other considerations. Essentially every issue discussed below could be pursued more rapidly and in more depth should one or more of these fundamental advances be made.
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ISSN:0019-9567
1098-5522
DOI:10.1128/IAI.61.4.1169-1172.1993