Antihepatitis C virus status in hepatocellular carcinoma and the influence on clinicopathological findings and operative results

Antihepatitis C virus (HCV) status was investigated in 100 patients undergoing hepatectomy for hepatocellular carcinoma (HCC) between 1980 and 1989. The clinicopathological findings and operative results, in patients with or without HCV marker, were compared retrospectively. The positivity rate of a...

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Published inBritish journal of surgery Vol. 79; no. 11; p. 1195
Main Authors Takeda, S, Nagafuchi, Y, Tashiro, H, Abe, Y, Fukushige, H, Komori, H, Okamoto, K, Ohsato, K, Haratake, J
Format Journal Article
LanguageEnglish
Published England 01.11.1992
Subjects
Adult
Aged
Aged, 80 and over
Biomarkers
Carcinoma, Hepatocellular - microbiology
Carcinoma, Hepatocellular - pathology
Carcinoma, Hepatocellular - surgery
Female
Hepacivirus - immunology
Hepacivirus - isolation & purification
Hepatitis Antibodies - analysis
Hepatitis C - immunology
Hepatitis C - surgery
Hepatitis C Antibodies
Humans
Liver Neoplasms - microbiology
Liver Neoplasms - pathology
Liver Neoplasms - surgery
Male
Middle Aged
Retrospective Studies
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Summary:Antihepatitis C virus (HCV) status was investigated in 100 patients undergoing hepatectomy for hepatocellular carcinoma (HCC) between 1980 and 1989. The clinicopathological findings and operative results, in patients with or without HCV marker, were compared retrospectively. The positivity rate of anti-HCV was 51 per cent. In this group there was a higher mean age, fewer symptoms, raised alanine aminotransferase level, higher 15-min indocyanine green clearance rate and earlier tumour stage compared with the anti-HCV negative group. Positive tumour margins and vascular invasion were seen less frequently in the anti-HCV positive group. HCC with HCV marker showed characteristic features of chronic non-A non-B hepatitis and of HCC originating from liver cirrhosis. There was a better cumulative 1-year survival rate for anti-HCV positive patients, but 3- and 5-year survival rates after hepatectomy were similar in both groups. Although HCV-related HCC had typical features of chronic non-A non-B hepatitis and a relatively early stage of tumour, biological features and operative results were similar with or without the HCV marker.
ISSN:0007-1323
DOI:10.1002/bjs.1800791131