DPP-4 as a Possible Biomarker of Inflammation Before Abdominal Surgery for Chronic Pathology: Our Experience with Elective Cholecystectomy

• Published in: Medicina (Kaunas, Lithuania) Vol. 55; no. 5; p. 148
• Main Authors: Valencia-Sánchez, Liliana, Almendra-Pegueros, Rafael, R-Valdez, Luis Jose Diaz, Esmer-Sánchez, David, Medina, Úrsula, Gordillo-Moscoso, Antonio
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI 16.05.2019; MDPI AG
• Subjects: Adolescent; Adult; Aged; biomarker; Biomarkers - analysis; Biomarkers - blood; cholecystectomy; Cholecystectomy - methods; Cholecystectomy - trends; Chronic Disease; Cohort Studies; Cross-Sectional Studies; Digestive System Surgical Procedures - methods; Dipeptidyl Peptidase 4 - analysis; Dipeptidyl Peptidase 4 - blood; dipeptidyl peptidase-4; Female; Humans; Inflammation - blood; Inflammation - physiopathology; Male; Middle Aged; pathology; perivesicular inflammation; Prospective Studies; surgical; surgical; perivesicular inflammation; cholecystectomy; pathology; biomarker; dipeptidyl peptidase-4
• ISSN: 1648-9144; 1010-660X; 1648-9144; 1010-660X
• DOI: 10.3390/medicina55050148

Dipeptidyl-Peptidase 4 (DPP-4) is a protein expressed in numerous cells and tissues. Recently it has shown its involvement as a catalyst in the inflammatory response in various pulmonary, autoimmune, intestinal and other pathologies. The objective of this study was to compare the preoperative serum levels of DPP-4 in patients with and without surgical finding of perivesicular inflammation. : a cross-sectional analytical study nested in a prospective cohort, including patients scheduled for elective cholecystectomy, without surgical complications, that were 18-70 years of age, with low cardiovascular risk, without a history of peritonitis, pancreatitis, or jaundice and underwent ERCP protocol, type 2 diabetes mellitus, acute inflammatory (Protein C Reactive < 3 mg/L, leucocytes < 10 1000/mm ), neoplastic, nephrologic or liver disease, the use of anti-inflammatory drugs, steroids and/or antibiotics, the use of pacemakers or metallic implants and without major amputations and whom agreed to participate by providing their informed consent. Ethical and Research register: 45-16. Prior to surgery we compiled anthropometric data and a blood sample to determine the serum levels of DPP-4. The presence of perivesicular inflammation was determined in the surgery. The data was analyzed using the statistical program Rstudio. : High BMI values were observed (27.8 ± 6.4); waist circumference (94.7 ± 15.1) and percentage of fat mass (34.7 ± 11.7), showing a cumulative frequency of 65.9% for overweight/obesity. In 27.3% of the interventions, intraoperative perivesicular inflammation findings were reported. The serum levels of DPP-4 were lower in the group of patients with perivesicular inflammation (3947.6 ± 1659.5 vs. 3053.2 ± 1469.6, LC95% of the difference: 160.4-1628.3), being statistically significant ( = 0.018). : In the subacute or chronic phases of cholecystitis, there appears to be a constant consumption of DPP-4, which would modulate a better immune response that could be related to the reduction of postoperative complications, so the use of Serum levels of DPP-4 as an early biomarker could improve the diagnostic accuracy of this pathology and the surgical approach.