Role of matrix vesicles in biomineralization

• Published in: Biochimica et biophysica acta Vol. 1790; no. 12; pp. 1592 - 1598
• Main Author: Golub, Ellis E.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.12.2009
• Subjects: Alkaline phosphatase; Animals; Biomineralization; Bone and Bones - metabolism; Calcification; Calcification, Physiologic - physiology; Cytoplasmic Vesicles - metabolism; Cytoplasmic Vesicles - physiology; Extracellular Matrix - physiology; Humans; Hydroxyapatite; Matrix vesicles; Minerals - metabolism; Models, Biological; Nucleation; Calcification; Biomineralization; Alkaline phosphatase; Hydroxyapatite; Nucleation; Matrix vesicles

Matrix vesicles have been implicated in the mineralization of calcified cartilage, bone and dentin for more than 40 years. During this period, their exact role, if any in the nucleation of hydroxyapatite mineral, and its subsequent association with the collagen fibrils in the organic matrix has been...