Mesoporous Strontium-Doped Phosphate-Based Sol-Gel Glasses for Biomedical Applications

Mesoporous phosphate-based glasses have great potential as biomedical materials being able to simultaneously induce tissue regeneration and controlled release of therapeutic molecules. In the present study, a series of mesoporous phosphate-based glasses in the P O -CaO-Na O system, doped with 1, 3,...

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Published inFrontiers in chemistry Vol. 8; p. 249
Main Authors Foroutan, Farzad, Kyffin, Benjamin Alexander, Abrahams, Isaac, Knowles, Jonathan C, Sogne, Elisa, Falqui, Andrea, Carta, Daniela
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 23.04.2020
Subjects
bioresorbable glasses
Chemistry
phosphate-based glasses
sol-gel
strontium-doped
tissue engineering
phosphate-based glasses
strontium-doped
tissue engineering
bioresorbable glasses
sol-gel
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Summary:Mesoporous phosphate-based glasses have great potential as biomedical materials being able to simultaneously induce tissue regeneration and controlled release of therapeutic molecules. In the present study, a series of mesoporous phosphate-based glasses in the P O -CaO-Na O system, doped with 1, 3, and 5 mol% of Sr , were prepared using the sol-gel method combined with supramolecular templating. A sample without strontium addition was prepared for comparison. The non-ionic triblock copolymer EO PO EO (P123) was used as a templating agent. Scanning electron microscopy (SEM) images revealed that all synthesized glasses have an extended porous structure. This was confirmed by N adsorption-desorption analysis at 77 K that shows a porosity typical of mesoporous materials. P magic angle spinning nuclear magnetic resonance ( P MAS-NMR) and Fourier transform infrared (FTIR) spectroscopies have shown that the glasses are mainly formed by Q and Q phosphate groups. Degradation of the glasses in deionized water assessed over a 7-day period shows that phosphate, Ca , Na , and Sr ions can be released in a controlled manner over time. In particular, a direct correlation between strontium content and degradation rate was observed. This study shows that Sr-doped mesoporous phosphate-based glasses have great potential in bone tissue regeneration as materials for controlled delivery of therapeutic ions.
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Reviewed by: Xue Liu, Liaoning University, China; Zhipeng Gu, Sun Yat-sen University, China; Xin Du, University of Science and Technology Beijing, China
This article was submitted to Nanoscience, a section of the journal Frontiers in Chemistry
Edited by: Tianyi Ma, University of Newcastle, Australia
ISSN:2296-2646
2296-2646
DOI:10.3389/fchem.2020.00249