circRNAs: Insight Into Their Role in Tumor-Associated Macrophages

Currently, it is well known that the tumor microenvironment not only provides energy support for tumor growth but also regulates tumor signaling pathways and promotes the proliferation, invasion, metastasis, and drug resistance of tumor cells. The tumor microenvironment, especially the function and...

Full description

Saved in:
Bibliographic Details
Published inFrontiers in oncology Vol. 11; p. 780744
Main Authors Duan, Saili, Wang, Shan, Huang, Tao, Wang, Junpu, Yuan, Xiaoqing
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 01.12.2021
Subjects
cancer
circRNA
M2 macrophage
Oncology
polarization
TAMs
M2 macrophage
cancer
polarization
TAMs
circRNA
Online AccessGet full text

Cover

More Information
Summary:Currently, it is well known that the tumor microenvironment not only provides energy support for tumor growth but also regulates tumor signaling pathways and promotes the proliferation, invasion, metastasis, and drug resistance of tumor cells. The tumor microenvironment, especially the function and mechanism of tumor-associated macrophages (TAMs), has attracted great attention. TAMs are the most common immune cells in the tumor microenvironment and play a vital role in the occurrence and development of tumors. circular RNA (circRNA) is a unique, widespread, and stable form of non-coding RNA (ncRNA), but little is known about the role of circRNAs in TAMs or how TAMs affect circRNAs. In this review, we summarize the specific manifestations of circRNAs that affect the tumor-associated macrophages and play a significant role in tumor progression. This review helps improve our understanding of the association between circRNAs and TAMs, thereby promoting the development and progress of potential clinical targeted therapies.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Edited by: Shiv K. Gupta, Mayo Clinic, United States
This article was submitted to Molecular and Cellular Oncology, a section of the journal Frontiers in Oncology
These authors have contributed equally to this work
Reviewed by: Giovanna Lucia Liguori, Institute of Genetics and Biophysics (CNR), Italy; Zehuan Liao, Nanyang Technological University, Singapore; Peng Wei, Beijing University of Chinese Medicine, China
ISSN:2234-943X
2234-943X
DOI:10.3389/fonc.2021.780744