Effect of Gene-Based Warfarin Dosing on Anticoagulation Control and Clinical Events in a Real-World Setting

• Published in: Frontiers in pharmacology Vol. 10; p. 1527
• Main Authors: Zhang, Jinhua, Wu, Tingting, Chen, Wenjun, Fu, Jinglan, Xia, Xiaotong, Chen, Liangwan
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 17.01.2020
• Subjects: CYP2C9; pharmacogenetics; Pharmacology; precision medicine; VKORC1; warfarin; VKORC1; CYP2C9; precision medicine; pharmacogenetics; warfarin
• ISSN: 1663-9812; 1663-9812
• DOI: 10.3389/fphar.2019.01527

The and genotypes are associated with anticoagulation control and the clinical events in warfarin therapy. However, the clinical utility of gene-based warfarin dosing (GBWD) is controversial. We compared the anticoagulation control and clinical events related to warfarin with GBWD to those with clinically fixed dosing (CFD). A retrospective cohort study was conducted in a real-world setting. Of the 915 patients who were reviewed, 844 patients met the study-entry criteria; 413 cases were guided by GBWD using the International Warfarin Pharmacogenetic Consortium algorithm; 431 cases were guided by CFD (2.5 mg/day). The primary outcomes were the time needed to achieve the therapeutic International Normalized Ratio (INR) and the time in the therapeutic range (TTR) during a 3-month timeframe. The time needed to achieve the therapeutic INR (in days) for patients in the GBWD group was shorter than that for patients in the CFD group (10.21 ± 4.68 14.31 ± 8.26, P < 0.001). The overall TTR (Day 4-90) was significantly different between the GBWD group and CFD group (56.86 ± 10.72 vs. 52.87 ± 13.92, P = 0.007).In subgroup analysis, the TTR was also significantly different between the GBWD group and CFD group during the first month of treatment (Day 4-14: 54.28 ± 21.90 47.01 ± 26.25, = 0.012; Day 15-28: 59.60 ± 20.12 51.71 ± 18.96, = 0.001). However, no significant difference in the TTR was observed after 29 days of treatment. These data suggest that GBWD provided clinical benefits.