The Trade-Off between Dietary Salt and Cardiovascular Disease; A Role for Na/K-ATPase Signaling?

It has been postulated for some time that endogenous digitalis-like substances, also called cardiotonic steroids (CTS), exist, and that these substances are involved in sodium handling. Within the past 20 years, these substances have been unequivocally identified and measurements of circulating and...

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Published inFrontiers in endocrinology (Lausanne) Vol. 5; p. 97
Main Authors Xie, Joe X, Shapiro, Anna Pearl, Shapiro, Joseph Isaac
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 01.01.2014
Subjects
Cardiotonic steroids
Endocrinology
Fibrosis
Hypertension
renal failure
signaling
sodium pump
cardiotonic steroids
digitalis-like factors
signaling
sodium pump
renal failure
fibrosis
hypertension
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Summary:It has been postulated for some time that endogenous digitalis-like substances, also called cardiotonic steroids (CTS), exist, and that these substances are involved in sodium handling. Within the past 20 years, these substances have been unequivocally identified and measurements of circulating and tissue concentrations have been made. More recently, it has been identified that CTS also mediate signal transduction through the Na/K-ATPase, and consequently been implicated in profibrotic pathways. This review will discuss the mechanism of CTS in renal sodium handling and a potential "trade-off" effect from their role in inducing tissue fibrosis.
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ObjectType-Review-1
Reviewed by: Gert Jansen, Erasmus MC, Netherlands; Harvey Craig Gonick, University of California Berkeley, USA; Neal S. Bricker, University of California Los Angeles School of Medicine, USA
Edited by: Harvey Craig Gonick, University of California Berkeley, USA
This article was submitted to Neuroendocrine Science, a section of the journal Frontiers in Endocrinology.
ISSN:1664-2392
1664-2392
DOI:10.3389/fendo.2014.00097