Methyladenosine Modification in RNAs: Classification and Roles in Gastrointestinal Cancers

Cellular ribonucleic acids (RNAs), including messenger RNAs (mRNAs) and non-coding RNAs (ncRNAs), harbor more than 150 forms of chemical modifications, among which methylation modifications are dynamically regulated and play significant roles in RNA metabolism. Recently, dysregulation of RNA methyla...

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Published inFrontiers in oncology Vol. 10; p. 586789
Main Authors Li, Qinghai, He, Weiling, Wan, Guohui
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 01.02.2021
Subjects
gastrointestinal cancers
m1A
m6A
m6Am
methylation modification
Oncology
RNA
gastrointestinal cancers
m6A
methylation modification
RNA
m1A
m6Am
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Summary:Cellular ribonucleic acids (RNAs), including messenger RNAs (mRNAs) and non-coding RNAs (ncRNAs), harbor more than 150 forms of chemical modifications, among which methylation modifications are dynamically regulated and play significant roles in RNA metabolism. Recently, dysregulation of RNA methylation modifications is found to be linked to various physiological bioprocesses and many human diseases. Gastric cancer (GC) and colorectal cancer (CRC) are two main gastrointestinal-related cancers (GIC) and the most leading causes of cancer-related death worldwide. In-depth understanding of molecular mechanisms on GIC can provide important insights in developing novel treatment strategies for GICs. In this review, we focus on the multitude of epigenetic changes of RNA methlyadenosine modifications in gene expression, and their roles in GIC tumorigenesis, progression, and drug resistance, and aim to provide the potential therapeutic regimens for GICs.
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Reviewed by: Huabing Li, Shanghai Jiao Tong University School of Medicine, China; Ye Wang, Peking University, China
This article was submitted to Cancer Genetics, a section of the journal Frontiers in Oncology
Edited by: Shicheng Guo, University of Wisconsin-Madison, United States
ISSN:2234-943X
2234-943X
DOI:10.3389/fonc.2020.586789