Myofilament Calcium Sensitivity: Role in Regulation of In vivo Cardiac Contraction and Relaxation

Myofilament calcium sensitivity is an often-used indicator of cardiac muscle function, often assessed in disease states such as hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM). While assessment of calcium sensitivity provides important insights into the mechanical force-generating...

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Published inFrontiers in physiology Vol. 7; p. 562
Main Authors Chung, Jae-Hoon, Biesiadecki, Brandon J, Ziolo, Mark T, Davis, Jonathan P, Janssen, Paul M L
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 16.12.2016
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Summary:Myofilament calcium sensitivity is an often-used indicator of cardiac muscle function, often assessed in disease states such as hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM). While assessment of calcium sensitivity provides important insights into the mechanical force-generating capability of a muscle at steady-state, the dynamic behavior of the muscle cannot be sufficiently assessed with a force-pCa curve alone. The equilibrium dissociation constant (K ) of the force-pCa curve depends on the ratio of the apparent calcium association rate constant (k ) and apparent calcium dissociation rate constant (k ) of calcium on TnC and as a stand-alone parameter cannot provide an accurate description of the dynamic contraction and relaxation behavior without the additional quantification of k or k , or actually measuring dynamic twitch kinetic parameters in an intact muscle. In this review, we examine the effect of length, frequency, and beta-adrenergic stimulation on myofilament calcium sensitivity and dynamic contraction in the myocardium, the effect of membrane permeabilization/mechanical- or chemical skinning on calcium sensitivity, and the dynamic consequences of various myofilament protein mutations with potential implications in contractile and relaxation behavior.
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Edited by: P. Bryant Chase, Florida State University, USA
Reviewed by: Beata M. Wolska, University of Illinois at Chicago, USA; David Grant Allen, University of Sydney, Australia; Rosana A. Bassani, University of Campinas, Brazil; Bertrand C. W. Tanner, Washington State University, USA
This article was submitted to Striated Muscle Physiology, a section of the journal Frontiers in Physiology
ISSN:1664-042X
1664-042X
DOI:10.3389/fphys.2016.00562