Titrating the Smell of Fear: Initial Evidence for Dose-Invariant Behavioral, Physiological, and Neural Responses

• Published in: Psychological science Vol. 32; no. 4; pp. 558 - 572
• Main Authors: de Groot, Jasper H. B., Kirk, Peter A., Gottfried, Jay A.
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 01.04.2021; SAGE PUBLICATIONS, INC
• Subjects: Ambiguity; Bayes Theorem; Bayesian analysis; Behavior; Bias; Disgust; Dosage; Emotional regulation; Emotions; Fear; Fear & phobias; Female; Human body; Humans; Magnetic resonance imaging; Male; Males; Men; Neuroimaging; Null hypothesis; Odorants; Odors; Physiology; Smell; Stimulus; Women; functional MRI; amygdala; dose response; social cognition; sniff; sweat; olfaction; open materials; communication; open data; fear; morph task
• ISSN: 0956-7976; 1467-9280
• DOI: 10.1177/0956797620970548

It is well accepted that emotional intensity scales with stimulus strength. Here, we used physiological and neuroimaging techniques to ask whether human body odor—which can convey salient social information—also induces dose-dependent effects on behavior, physiology, and neural responses. To test this, we first collected sweat from 36 males classified as low-, medium-, and high-fear responders. Next, in a double-blind within-subjects functional-MRI design, 31 women were exposed to three doses of fear-associated human chemosignals and neutral sweat while viewing face morphs varying between expressions of fear and disgust. Behaviorally, we found that all doses of fear-sweat volatiles biased participants toward perceiving fear in ambiguous morphs, a dose-invariant effect generally repeated across physiological and neural measures. Bayesian dose-response analysis indicated moderate evidence for the null hypothesis (except for the left amygdala), tentatively suggesting that the human olfactory system engages an all-or-none mechanism for tagging fear above a minimal threshold.