Caveolin-1 and Caveolin-2 Can Be Antagonistic Partners in Inflammation and Beyond

Caveolins, encoded by the CAV gene family, are the main protein components of caveolae. In most tissues, caveolin-1 (Cav-1) and caveolin-2 (Cav-2) are co-expressed, and Cav-2 targeting to caveolae depends on the formation of heterooligomers with Cav-1. Notwithstanding, Cav-2 has unpredictable activi...

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Published inFrontiers in immunology Vol. 8; p. 1530
Main Author de Almeida, Cecília Jacques Gonçalves
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 17.11.2017
Subjects
caveolae
caveolin
fibrosis
Immunology
infection
inflammation
proliferation
infection
signaling
proliferation
inflammation
endocytosis
fibrosis
caveolae
caveolin
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Summary:Caveolins, encoded by the CAV gene family, are the main protein components of caveolae. In most tissues, caveolin-1 (Cav-1) and caveolin-2 (Cav-2) are co-expressed, and Cav-2 targeting to caveolae depends on the formation of heterooligomers with Cav-1. Notwithstanding, Cav-2 has unpredictable activities, opposing Cav-1 in the regulation of some cellular processes. While the major roles of Cav-1 as a modulator of cell signaling in inflammatory processes and in immune responses have been extensively discussed elsewhere, the aim of this review is to focus on data revealing the distinct activity of Cav-1 and Cav-2, which suggest that these proteins act antagonistically to fine-tune a variety of cellular processes relevant to inflammation.
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Specialty section: This article was submitted to Inflammation, a section of the journal Frontiers in Immunology
Reviewed by: Yanlin He, Baylor College of Medicine, United States; Bernardo Louis Trigatti, McMaster University, Canada
Edited by: Kai Fang, University of California, Los Angeles, United States
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2017.01530