Clinicopathological Significance of EBV-Infected Gastric Carcinomas: A Meta-Analysis

• Published in: Medicina (Kaunas, Lithuania) Vol. 56; no. 7; p. 345
• Main Authors: Pyo, Jung-Soo, Kim, Nae-Yu, Kang, Dong-Wook
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI 13.07.2020; MDPI AG
• Subjects: B7-H1 Antigen - analysis; Biomarkers - analysis; clinicopathological characteristics; DNA-Binding Proteins - analysis; Epstein-Barr Virus Infections - complications; Epstein-Barr Virus Infections - physiopathology; Epstein–Barr virus; gastric carcinoma; Herpesvirus 4, Human; histologic type; Humans; meta-analysis; Microsatellite Instability; Peptide Fragments - analysis; Receptor, ErbB-2 - analysis; Stomach Neoplasms - classification; Stomach Neoplasms - physiopathology; Transcription Factors - analysis; Tumor Suppressor Protein p53 - analysis; meta-analysis; clinicopathological characteristics; gastric carcinoma; Epstein–Barr virus; histologic type
• ISSN: 1648-9144; 1010-660X; 1648-9144
• DOI: 10.3390/medicina56070345

: The present study aims to elucidate the clinicopathologic significance of Epstein-Barr virus (EBV) infection in gastric carcinomas (GCs) through a meta-analysis. : Sixty-one eligible studies were included in the present meta-analysis. The included patients, with and without EBV infection, were 2063 and 17,684, respectively. We investigated the clinicopathologic characteristics and various biomarkers, including programmed death-ligand 1 (PD-L1) expression and tumor-infiltrating lymphocytes (TILs). : The estimated EBV-infected rate of GCs was 0.113 (95% confidence interval (CI): 0.088-0.143). The EBV infection rates in GC cells were 0.138 (95% CI: 0.096-0.194), 0.103 (95% CI: 0.077-0.137), 0.080 (95% CI: 0.061-0.106), and 0.042 (95% CI: 0.016-0.106) in the population of Asia, America, Europe, and Africa, respectively. There was a significant difference between EBV-infected and noninfected GCs in the male: female ratio, but not other clinicopathological characteristics. EBV infection rates were higher in GC with lymphoid stroma (0.573, 95% CI: 0.428-0.706) than other histologic types of GCs. There were significant differences in high AT-rich interactive domain-containing protein 1A (ARID1A) and PD-L1 expressions, and high CD8+ TILs between EBV-infected and noninfected GCs. : Our results showed that EBV infection of GCs was frequently found in male patients and GCs with lymphoid stroma. EBV infection was significantly correlated with ARID1A and PD-L1 expressions and CD8+ TILs in GCs.