The role of antibiotic prophylaxis in lichtenstein repair of primary inguinal hernia: A prospective double-blind randomized placebo-controlled trial

Objective: The objective is to study the role of antibiotic prophylaxis, if any, in the prevention of wound infection after open mesh repair of primary inguinal hernias. Materials and Methods: Patients coming to outpatient department for open mesh repair of inguinal hernia were randomized into the p...

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Published inNigerian journal of surgery Vol. 27; no. 1; pp. 5 - 8
Main Authors Jain, Sudhir, Hameed, Tariq, Jain, Dhruv, Singh, Mohak, Nizam, Adiba
Format Journal Article
LanguageEnglish
Published India Wolters Kluwer India Pvt. Ltd 01.01.2021
Medknow Publications and Media Pvt. Ltd
Wolters Kluwer - Medknow
Wolters Kluwer Medknow Publications
Subjects
antibiotic
Antibiotics
Clinical trials
Health aspects
Infection
Infection control
Inguinal hernia
Medical research
Medicine, Experimental
mesh inguinal hernia repair
Original
prophylaxis
prophylaxis
Antibiotic
mesh inguinal hernia repair
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Summary:Objective: The objective is to study the role of antibiotic prophylaxis, if any, in the prevention of wound infection after open mesh repair of primary inguinal hernias. Materials and Methods: Patients coming to outpatient department for open mesh repair of inguinal hernia were randomized into the placebo group and antibiotic group, a total of 150 patients were enrolled in the study. Follow-up was done up to 1 month to look for any evidence of surgical site infection using the criteria of Centers for Disease Control on wound infection. Results: Twelve patients in the antibiotic group and nine patients in the placebo group were found to have evidence of surgical site infection. This difference was found to be insignificant with P = 0.14. Three patients in the placebo group developed deep surgical site infection but on analysis, this difference was also found to be insignificant with P = 0.122.None of these patients required mesh removal. Conclusion: The result of the present study suggests that the use of prophylactic antibiotics during mesh repair of primary inguinal hernias does not give any extra protection from infections. Multicenter meta-analysis is required to give definite guidelines regarding the use of prophylactic antibiotics.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1117-6806
2278-7100
DOI:10.4103/njs.NJS_52_19