ANGPTL8: An Important Regulator in Metabolic Disorders

Long-term controversy regarding the role of angiopoietin-like protein 8 (ANGPTL8) in beta-cell proliferation and diabetes progression made it a research spotlight. Recently, the controversy was resolved. Although ANGPTL8 could not control beta-cell expansion and islet function, ANGPTL8 was still con...

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Published inFrontiers in endocrinology (Lausanne) Vol. 9; p. 169
Main Authors Luo, Mengdie, Peng, Daoquan
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 17.04.2018
Subjects
angiopoietin-like protein 8
ANGPTL3
diabetes mellitus
diet
Endocrinology
triglyceride
triglyceride
ANGPTL3
diabetes mellitus
diet
angiopoietin-like protein 8
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Summary:Long-term controversy regarding the role of angiopoietin-like protein 8 (ANGPTL8) in beta-cell proliferation and diabetes progression made it a research spotlight. Recently, the controversy was resolved. Although ANGPTL8 could not control beta-cell expansion and islet function, ANGPTL8 was still considered as a novel but atypical member in the ANGPTL family because of its unique structure and crucial effects on lipid metabolism. Besides, ANGPTL8 also participated in some other disorders such as non-alcoholic fatty liver disease and renal dysfunction. Understanding the features of ANGPTL8 may offer new diagnostic and therapeutic approaches to metabolic-related diseases. Therefore, we reviewed most recent findings about ANGPTL8 and aimed to provide an integrated picture of ANGPTL8.
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Edited by: Romain Barrès, University of Copenhagen, Denmark
Reviewed by: Sana Siddiqui, University of California, San Francisco, United States; David Simar, University of New South Wales, Australia
Specialty section: This article was submitted to Molecular and Structural Endocrinology, a section of the journal Frontiers in Endocrinology
ISSN:1664-2392
1664-2392
DOI:10.3389/fendo.2018.00169