Regulation of Type 2 Immunity in Myocardial Infarction

Type 2 immunity participates in the pathogeneses of helminth infection and allergic diseases. Emerging evidence indicates that the components of type 2 immunity are also involved in maintaining metabolic hemostasis and facilitating the healing process after tissue injury. Numerous preclinical studie...

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Published inFrontiers in immunology Vol. 10; p. 62
Main Authors Xu, Jun-Yan, Xiong, Yu-Yan, Lu, Xiao-Tong, Yang, Yue-Jin
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 2019
Subjects
Animals
Cell Polarity
Collagen - metabolism
Disease Models, Animal
eosinophils
Eosinophils - immunology
Humans
Immunity, Innate
Immunology
Inflammation - immunology
interleukin
Interleukins - biosynthesis
M2 macrophages
Macrophages - immunology
mast cells
Mast Cells - immunology
Mice
myocardial infarction
Myocardial Infarction - immunology
Myocardial Infarction - pathology
Neovascularization, Physiologic - immunology
Rats
type 2 immunity
M2 macrophages
myocardial infarction
eosinophils
immune modulation
interleukin
mast cells
type 2 immunity
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Summary:Type 2 immunity participates in the pathogeneses of helminth infection and allergic diseases. Emerging evidence indicates that the components of type 2 immunity are also involved in maintaining metabolic hemostasis and facilitating the healing process after tissue injury. Numerous preclinical studies have suggested regulation of type 2 immunity-related cytokines, such as interleukin-4, -13, and -33, and cell types, such as M2 macrophages, mast cells, and eosinophils, affects cardiac functions after myocardial infarction (MI), providing new insights into the importance of immune modulation in the infarcted heart. This review provides an overview of the functions of these cytokines and cells in the setting of MI as well as their potential to predict the severity and prognosis of MI.
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These authors have contributed equally to this work
This article was submitted to Inflammation, a section of the journal Frontiers in Immunology
Reviewed by: Rui Li, University of Pennsylvania, United States; Maryna Skok, Palladin Institute of Biochemistry (NAS Ukraine), Ukraine
Edited by: Mohamed Boutjdir, Veterans Affairs New York Harbor Healthcare System, United States
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2019.00062