GRP78 induction in cancer : Therapeutic and prognostic implications

Cancer cells adapt to chronic stress in the tumor microenvironment by inducing the expression of GRP78/BiP, a major endoplasmic reticulum chaperone with Ca(2+)-binding and antiapoptotic properties. GRP78 promotes tumor proliferation, survival, metastasis, and resistance to a wide variety of therapie...

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Bibliographic Details
Published inCancer research (Chicago, Ill.) Vol. 67; no. 8; pp. 3496 - 3499
Main Author LEE, Amy S
Format Journal Article
LanguageEnglish
Published Philadelphia, PA American Association for Cancer Research 15.04.2007
Subjects
Antineoplastic agents
Biological and medical sciences
Biomarkers, Tumor - biosynthesis
Heat-Shock Proteins - biosynthesis
Humans
Medical sciences
Molecular Chaperones - biosynthesis
Neoplasms - diagnosis
Neoplasms - metabolism
Neoplasms - therapy
Pharmacology. Drug treatments
Prognosis
Tumors
Prognosis
Treatment
Malignant tumor
Induction
Cancer
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Summary:Cancer cells adapt to chronic stress in the tumor microenvironment by inducing the expression of GRP78/BiP, a major endoplasmic reticulum chaperone with Ca(2+)-binding and antiapoptotic properties. GRP78 promotes tumor proliferation, survival, metastasis, and resistance to a wide variety of therapies. Thus, GRP78 expression may serve as a biomarker for tumor behavior and treatment response. Combination therapy suppressing GRP78 expression may represent a novel approach toward eradication of residual tumors. Furthermore, the recent discovery of GRP78 on the cell surface of cancer cells but not in normal tissues suggests that targeted therapy against cancer via surface GRP78 may be feasible.
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ISSN:0008-5472
1538-7445
DOI:10.1158/0008-5472.CAN-07-0325