Global Studies of Using Fecal Biomarkers in Predicting Relapse in Inflammatory Bowel Disease

Inflammatory bowel disease (IBD) is a chronic inflammatory condition of the gastrointestinal tract mainly comprising two forms including Crohn's disease (CD) and ulcerative colitis (UC). IBD is a lifelong relapsing remitting disease and relapses occur at random patterns which are unpredictable....

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Published inFrontiers in medicine Vol. 7; p. 580803
Main Authors Liu, Fang, Lee, Seul A, Riordan, Stephen M, Zhang, Li, Zhu, Lixin
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 17.12.2020
Subjects
calprotectin
Crohn's disease
fecal biomarkers
inflammatory bowel disease
Medicine
prediction
ulcerative colitis
calprotectin
lactoferrin
prediction
S100A12
Crohn's disease
ulcerative colitis
fecal biomarkers
inflammatory bowel disease
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Summary:Inflammatory bowel disease (IBD) is a chronic inflammatory condition of the gastrointestinal tract mainly comprising two forms including Crohn's disease (CD) and ulcerative colitis (UC). IBD is a lifelong relapsing remitting disease and relapses occur at random patterns which are unpredictable. Fecal biomarkers have been increasingly used to assess disease activity in IBD due to their positive correlations with intestinal inflammation. Recent studies have also assessed the use of fecal biomarkers in predicting relapse and post-operative recurrence. This review provides information from global studies of using fecal calprotectin, lactoferrin and S100A12 to predict relapse in IBD. Strategies for further studies and the use of these fecal biomarkers for personalized management in IBD are also discussed.
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Reviewed by: Yong Hua Sheng, University of Queensland, Australia; Edouard Louis, University of Liège, Belgium
Edited by: Fernando Gomollón, University of Zaragoza, Spain
This article was submitted to Gastroenterology, a section of the journal Frontiers in Medicine
ISSN:2296-858X
2296-858X
DOI:10.3389/fmed.2020.580803