Tandem Repeats in Proteins: Prediction Algorithms and Biological Role

Tandem repetitions in protein sequence and structure is a fascinating subject of research which has been a focus of study since the late 1990s. In this survey, we give an overview on the multi-faceted aspects of research on protein tandem repeats (PTR for short), including prediction algorithms, dat...

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Bibliographic Details
Published inFrontiers in bioengineering and biotechnology Vol. 3; p. 143
Main Author Pellegrini, Marco
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 01.01.2015
Subjects
Bioengineering and Biotechnology
Biological significance
Protein TR Detection Algorithms
Protein TR properties
Proteins
tandem repeats
tandem repeats
protein TR properties
protein TR detection algorithms
biological significance
proteins
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Summary:Tandem repetitions in protein sequence and structure is a fascinating subject of research which has been a focus of study since the late 1990s. In this survey, we give an overview on the multi-faceted aspects of research on protein tandem repeats (PTR for short), including prediction algorithms, databases, early classification efforts, mechanisms of PTR formation and evolution, and synthetic PTR design. We also touch on the rather open issue of the relationship between PTR and flexibility (or disorder) in proteins. Detection of PTR either from protein sequence or structure data is challenging due to inherent high (biological) signal-to-noise ratio that is a key feature of this problem. As early in silico analytic tools have been key enablers for starting this field of study, we expect that current and future algorithmic and statistical breakthroughs will have a high impact on the investigations of the biological role of PTR.
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Specialty section: This article was submitted to Bioinformatics and Computational Biology, a section of the journal Frontiers in Bioengineering and Biotechnology
Edited by: John Hancock, The Genome Analysis Centre, UK
Reviewed by: Silvio C. E. Tosatto, University of Padua, Italy; Michelle M. Simon, Medical Research Council, UK
ISSN:2296-4185
2296-4185
DOI:10.3389/fbioe.2015.00143