Autopsy proven peripheral nervous system neurolymphomatosis despite negative bilateral sural nerve biopsy
Neurolymphomatosis (NL) refers to a lymphomatous infiltration of peripheral nerves associated with central nervous system or systemic lymphoma, or alternatively, neurodiagnostic evidence of nerve enhancement and/or enlargement beyond the dural sleeve in the setting of primary central nervous system...
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Published in | Frontiers in neurology Vol. 4; p. 197 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Switzerland
Frontiers Media S.A
01.01.2013
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Subjects | |
Online Access | Get full text |
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Summary: | Neurolymphomatosis (NL) refers to a lymphomatous infiltration of peripheral nerves associated with central nervous system or systemic lymphoma, or alternatively, neurodiagnostic evidence of nerve enhancement and/or enlargement beyond the dural sleeve in the setting of primary central nervous system lymphoma or systemic lymphoma. NL is a rare complication of systemic cancer with heterogeneous clinical presentations and an elusive diagnosis. Diagnosis usually requires the demonstration of infiltrating malignant lymphocytes in the peripheral nerve. Infiltration of brain parenchyma, meninges or Virchow-Robin spaces is characteristic of systemic disease at autopsy. We describe a patient presenting with biopsy negative NL affecting exclusively the peripheral nervous system at autopsy. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Edited by: Gregory Gruener, Loyola University, USA Reviewed by: Gregory Gruener, Loyola University, USA; Walter Struhal, Allgemeines Krankenhaus Linz, Austria This article was submitted to Neurology Education, a section of the journal Frontiers in Neurology. |
ISSN: | 1664-2295 1664-2295 |
DOI: | 10.3389/fneur.2013.00197 |