Autopsy proven peripheral nervous system neurolymphomatosis despite negative bilateral sural nerve biopsy

Neurolymphomatosis (NL) refers to a lymphomatous infiltration of peripheral nerves associated with central nervous system or systemic lymphoma, or alternatively, neurodiagnostic evidence of nerve enhancement and/or enlargement beyond the dural sleeve in the setting of primary central nervous system...

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Published inFrontiers in neurology Vol. 4; p. 197
Main Authors Ramirez-Zamora, Adolfo, Morales-Vidal, Sarkis, Chawla, Jasvinder, Biller, José
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 01.01.2013
Subjects
neurolymphomatosis
Neuroscience
non-Hodgkin lymphoma
peripheral neuropathy
neurolymphomatosis
peripheral neuropathy
non-Hodgkin lymphoma
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Summary:Neurolymphomatosis (NL) refers to a lymphomatous infiltration of peripheral nerves associated with central nervous system or systemic lymphoma, or alternatively, neurodiagnostic evidence of nerve enhancement and/or enlargement beyond the dural sleeve in the setting of primary central nervous system lymphoma or systemic lymphoma. NL is a rare complication of systemic cancer with heterogeneous clinical presentations and an elusive diagnosis. Diagnosis usually requires the demonstration of infiltrating malignant lymphocytes in the peripheral nerve. Infiltration of brain parenchyma, meninges or Virchow-Robin spaces is characteristic of systemic disease at autopsy. We describe a patient presenting with biopsy negative NL affecting exclusively the peripheral nervous system at autopsy.
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Edited by: Gregory Gruener, Loyola University, USA
Reviewed by: Gregory Gruener, Loyola University, USA; Walter Struhal, Allgemeines Krankenhaus Linz, Austria
This article was submitted to Neurology Education, a section of the journal Frontiers in Neurology.
ISSN:1664-2295
1664-2295
DOI:10.3389/fneur.2013.00197