How metabolic acidosis and oxidative stress alone and interacting may increase the risk of fracture in diabetic subjects

Subjects with either type 1 or type 2 diabetes are at higher risk for having fractures, a risk not necessarily improved by better glucose control. In this article, we argue that low grade metabolic acidosis and increased oxidative stress occurring in bone disease in part as a result of complications...

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Bibliographic Details
Published inMedical hypotheses Vol. 79; no. 2; pp. 189 - 192
Main Authors Frassetto, L.A., Sebastian, A.
Format Journal Article
LanguageEnglish
Published United States Elsevier Ltd 01.08.2012
Subjects
Acidosis - epidemiology
Acidosis - physiopathology
Comorbidity
Diabetes Complications - epidemiology
Diabetes Complications - physiopathology
Fractures, Spontaneous - epidemiology
Fractures, Spontaneous - physiopathology
Humans
Internal Medicine
Models, Biological
Oxidative Stress
Prevalence
Risk Factors
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Summary:Subjects with either type 1 or type 2 diabetes are at higher risk for having fractures, a risk not necessarily improved by better glucose control. In this article, we argue that low grade metabolic acidosis and increased oxidative stress occurring in bone disease in part as a result of complications of diabetes, reinforce each other, and together constitute a double jeopardy for the development of bone fractures in diabetic subjects.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0306-9877
1532-2777
1532-2777
DOI:10.1016/j.mehy.2012.04.031