Integrated nanozymes: facile preparation and biomedical applications

Nanozymes have been viewed as the next generation of artificial enzymes due to their low cost, large specific surface area, and good robustness under extreme conditions. However, the moderate activity and limited selectivity of nanozymes have impeded their usage. To overcome these shortcomings, inte...

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Published inChemical communications (Cambridge, England) Vol. 54; no. 5; pp. 652 - 653
Main Authors Wu, Jiangjiexing, Li, Sirong, Wei, Hui
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 19.06.2018
Subjects
Animals
biocatalysts
Biomedical materials
Biomimetic Materials - chemistry
Carbon - chemistry
Cascade chemical reactions
chemical compounds
chemical reactions
encapsulation
Enzymes
Enzymes - chemistry
Glucose - analysis
Hydrogels - chemistry
Metal-Organic Frameworks - chemistry
Nanoparticles - chemistry
Peroxidase
Reactive Oxygen Species - metabolism
Silicon Dioxide - chemistry
surface area
therapeutics
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Summary:Nanozymes have been viewed as the next generation of artificial enzymes due to their low cost, large specific surface area, and good robustness under extreme conditions. However, the moderate activity and limited selectivity of nanozymes have impeded their usage. To overcome these shortcomings, integrated nanozymes (INAzymes) have been developed by encapsulating two or more different biocatalysts ( e.g. , natural oxidases and peroxidase mimics) together within confined frameworks. On the one hand, with the assistance of natural enzymes, INAzymes are capable of specifically recognizing targets. On the other hand, nanoscale confinement brought about by integration significantly enhances the cascade reaction efficiency. In this Feature Article, we highlight the newly developed INAzymes, covering from synthetic strategies to versatile applications in biodetection and therapeutics. Moreover, it is predicted that INAzymes with superior activities, specificity, and stability will enrich the research of nanozymes and pave new ways in designing multifunctional nanozymes. Attributed to nanoscale proximity effects, integrated nanozymes with superior activities, specificity, and stability will be a hot topic in the future.
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ISSN:1359-7345
1364-548X
1364-548X
DOI:10.1039/c8cc01202d