Obesity May Accelerate the Aging Process

Lines of evidence from several studies have shown that increases in life expectancy are now accompanied by increased disability rate. The expanded lifespan of the aging population imposes a challenge on the continuous increase of chronic disease. The prevalence of overweight and obesity is increasin...

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Published inFrontiers in endocrinology (Lausanne) Vol. 10; p. 266
Main Authors Salvestrini, Valentina, Sell, Christian, Lorenzini, Antonello
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 03.05.2019
Subjects
aging
aging hallmarks
caloric restriction
Endocrinology
obesity
overweight
caloric restriction
aging
aging hallmarks
overweight
obesity
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Summary:Lines of evidence from several studies have shown that increases in life expectancy are now accompanied by increased disability rate. The expanded lifespan of the aging population imposes a challenge on the continuous increase of chronic disease. The prevalence of overweight and obesity is increasing at an alarming rate in many parts of the world. Further to increasing the onset of metabolic imbalances, obesity leads to reduced life span and affects cellular and molecular processes in a fashion resembling aging. Nine key hallmarks of the aging process have been proposed. In this review, we will review these hallmarks and discuss pathophysiological changes that occur with obesity, that are similar to or contribute to those that occur during aging. We present and discuss the idea that obesity, in addition to having disease-specific effects, may accelerate the rate of aging affecting all aspects of physiology and thus shortening life span and health span.
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Edited by: Alessandro Cellerino, Scuola Normale Superiore di Pisa, Italy
This article was submitted to Endocrinology of Aging, a section of the journal Frontiers in Endocrinology
Reviewed by: Alessandro Bitto, University of Washington, United States; Margherita Maffei, Italian National Research Council (CNR), Italy
ISSN:1664-2392
1664-2392
DOI:10.3389/fendo.2019.00266